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Center for Molecular Neurology
The research group focuses on the identification and characterization of genes and pathways implicated in the molecular etiology of inherited neurological disorders, like motor and sensory peripheral neuropathies and spastic paraplegias.
The research group focuses on the discovery and functional characterization of novel disease genes implicated in frontotemporal lobar degeneration (FTLD) and related disorders.
The research group aims to identify novel genes implicated in epilepsy, and improve our mechanistic understanding of epileptic disorders using a combination of (epi)genomics, transcriptomics, and model systems as human iPSCl derived neuronal cultures and brain organoids.
The research group aims to contribute to a better understanding of the genetic etiology of complex forms of Alzheimer dementia and related neurodegenerative diseases, by means of genetic-epidemiological and molecular genetic techniques
The research group perform translational neurogenetic research of frontotemporal dementia and early onset dementia on well-characterized patient collections. In addition to our gene-discovery research lines, we invest in translation of novel genetic findings into diagnostic and prognostic relevant genotype-phenotype correlations.
The research group address fundamental questions in chromatin organisation, epigenetics and brain biology. We develop machine learning approaches for large-scale data integration and reconstruct cis-regulatory networks to understand how a cell “chooses” its fate.
At CMN, we put our heart, soul, and skills into understanding complex neurodegenerative diseases of the central and peripheral nervous system. Working together to push the boundaries, we blend the best of our talents to unlock innovation. Will you join us in our pioneering adventure?
The research group studies gene mutations associated with Charcot-Marie-Tooth neuropathies to understand the delicate balance between peripheral nerve homeostasis and degeneration. From genetics we proceed with functional characterisation of specific mutations in cell and animal models, and we explore therapeutic approaches..
The research team studies the genetic basis and the clinical characteristics of neuromuscular diseases including peripheral neuropathies, myopathies and spastic paraplegias.