Research focus

Microglia and neuroinflammation play a central role in the pathogenesis of Alzheimer’s disease and other neurodegenerative disorders. Our primary focus is to examine the underlying molecular mechanisms that drive Alzheimer’s disease (AD) and Frontotemporal degeneration (FTD), with special focus on inflammatory networks and particularly the contribution of microglia. We use mouse models, iPSC and cutting-edge humanised mouse systems to determine the immune component of these disorders and determine how genetics alter microglial function and contribute to the initiation and perpetuation of brain disease.

Prof. Renzo Mancuso


fig 1: Representative confocal images showing widespread distribution of human microglia (stained both in red and green) across multiple brain regions 4 weeks after transplantation. The left panel displays a sagittal section of the mouse brain (2mm lateral from midline), whereas and the right panels show higher magnification images of cortex and hippocampus.

 

Team

Renzo Mancuso

Renzo Mancuso

Group Leader
Rita Cacace

Rita Cacace

Post-Doctoral Researcher
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Laura Fumagalli

Post-Doctoral Researcher
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Alma Mohebiany

Post-Doctoral Researcher
Teun Klein Gunnewiek

Teun Klein Gunnewiek

Post-Doctoral Researcher
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Nicola Fattorelli

Post-Doctoral Researcher
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Anika Perdok

Post-Doctoral Researcher
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Anna Martinez Muriana

Post-Doctoral Researcher
Jessie Premereur

Jessie Premereur

PhD student
Baukje Bijnens

Baukje Bijnens

PhD student
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Tijs Watzeels

PhD student
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Maxim van Hoek

PhD student
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Lena Jutz

PhD student
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Cindy Keller

PhD student
Heidi Denton

Heidi Denton

Technician
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Tim Meese

Technician
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Birgit Voeten

Technician
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Lien De Schepper

Master student
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Ulrieke Van Gestel

Master student
Mongia Bouchoucha

Mongia Bouchoucha

Master student