Research focus

Microglia and neuroinflammation play a central role in the pathogenesis of Alzheimer’s disease and other neurodegenerative disorders. Our primary focus is to examine the underlying molecular mechanisms that drive Alzheimer’s disease (AD) and Frontotemporal degeneration (FTD), with special focus on inflammatory networks and particularly the contribution of microglia. We use mouse models, iPSC and cutting-edge humanised mouse systems to determine the immune component of these disorders and determine how genetics alter microglial function and contribute to the initiation and perpetuation of brain disease.

Prof. Renzo Mancuso


fig 1: Representative confocal images showing widespread distribution of human microglia (stained both in red and green) across multiple brain regions 4 weeks after transplantation. The left panel displays a sagittal section of the mouse brain (2mm lateral from midline), whereas and the right panels show higher magnification images of cortex and hippocampus.

 

Team

Renzo Mancuso

Renzo Mancuso

Group Leader
Teun Klein Gunnewiek

Teun Klein Gunnewiek

Post-Doctoral Researcher
no picture available

Laura Fumagalli

Post-Doctoral Researcher
no picture available

Alma Mohebiany

Post-Doctoral Researcher
Jessie Premereur

Jessie Premereur

PhD student
Baukje Bijnens

Baukje Bijnens

PhD student
no picture available

Tijs Watzeels

PhD student
no picture available

Maxim van Hoek

PhD student
Heidi Denton

Heidi Denton

Technician
no picture available

Laura Alvarez Mendez

Master student
no picture available

Josephine Arndt

Master student