I joined the Center for Molecular Neurology VIB-UAntwerp in 2018 and aim to help elucidate the genetic etiology of Alzheimer's disease (AD). In order to do so I want to identify gene expression signatures of functional connectivity and cognitive decline by studying brain of deceased patients and control individuals with a combined genomics and transcriptomics approach.  Moreover, I'm also working on an in-depth characterization of ABCA7s transcriptome profile and splice isoforms, using RNA sequencing, long-read nanopore sequencing and western blot. 

  • De Roeck A, Duchateau L, Van Dongen J, Cacace R, Bjerke M, Van den Bossche T, Cras P, Vandenberghe R, De Deyn PP, Engelborghs S, Van Broeckhoven C, Sleegers K. An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer's disease. Acta Neuropathol. 2018;135(6):827-837, link
  • Duchateau L, Martín-Aguilar L, Lleixà C, Cortese A, Dols-Icardo O, Cervera-Carles L, et al. Absence of pathogenic mutations in CD59 in chronic inflammatory demyelinating polyradiculoneuropathy. PLoS ONE. 2019; 14(2): e0212647, link


  • Alzheimer's disease

  • dementia

  • complex genetics

  • transcriptomics

  • long-read sequencing

  • alternative splicing

  • ABCA7