Abdelkrim Azmi

Research Associate

+32 (3) 265.1030
Abdelkrim Azmi

Science

Presently my work primarily consists of: protein sample preparation for mass spectrometry; high-performance liquid chromatography; quantitative mass tag labelling based proteomics; quantitative interactomics; phosphoproteomics; quantitative metabolomics and molecular biology. My current work is strongly linked with the quantitative discovery of the molecular signatures, in tissues, human biofluids or cells, of major neurodegenerative diseases. These molecular signatures comprise the most predictive series of protein factors that can specifically define a disease process. In addition to primary data generation I am closely involved with secure data management and bioinformatics analysis.

Selected Publications:

  • De Ridder Willem, Azmi Abdelkrim, Clemen Christoph S., Eichinger Ludwig, Hofmann Andreas, Schröder Rolf, Johnson Katherine, Töpf Ana, Straub Volker, De Jonghe Peter, Maudsley Stuart, De Bleecker Jan L., Baets Jonathan. (2019) A tale of the unexpected: multisystem proteinopathy due to a homozygous p.Arg159His VCP mutation. Neurology (accepted).
  • Opdebeeck Britt, Maudsley Stuart, Azmi Abdelkrim, De Maré Annelies, De Leger Wout, Meijers Bjorn, Verhulst Anja, Evenepoel Pieter, d' Haese Patrick C., Neven Ellen. (2019) Indoxyl sulfate and p-cresyl sulfate promote vascular calcification and associate with glucose intolerance. Journal of the American Society of Nephrology - ISSN 1046-6673-30:5, p. 751-76
  • De Maré Annelies, Maudsley Stuart, Azmi Abdelkrim, Hendrickx Jhana, Opdebeeck Britt, Neven Ellen, d' Haese Patrick C., Verhulst Anja. (2019). Sclerostin as regulatory molecule in vascular media calcification and the bone–vascular axis. Toxins - ISSN 2072-6651-11:7.
  • Anckaerts Cynthia, van Gastel Jaana, Leysen Valerie, Hinz Rukun, Azmi Abdelkrim, Simoens Pascal, Shah Disha, Kara Firat, Langbeen An, Bols Peter, Laloux Charlotte, Prevot Vincent, Verhoye Marleen, Maudsley Stuart, Van Der Linden Anne-Marie. (2019). Image-guided phenotyping of ovariectomized mice: altered functional connectivity, cognition, myelination, and dopaminergic functionality. Neurobiology of aging - ISSN 0197-4580-74, p. 77-89.
  • Juneja M, Azmi A, Baets J, Roos A, Jennings MJ, Saveri P, Pisciotta C, Bernard-Marissal N, Schneider BL, Verfaillie C, Chrast R, Seeman P, Hahn AF, de Jonghe P, Maudsley S, Horvath R, Pareyson D, Timmerman V. (2018). PFN2 and GAMT as common molecular determinants of axonal Charcot-Marie-Tooth disease. J Neurol Neurosurg Psychiatry. PMID: 29449460.
  • Martin B, Wang R, Cong WN, Daimon CM, Wu WW, Ni B, Becker KG, Lehrmann E, Wood WH 3rd, Zhang Y, Etienne H, van Gastel J, Azmi A, Janssens J, Maudsley S. (2017). Altered learning, memory, and social behavior in type 1 taste receptor subunit 3 knock-out mice are associated with neuronal dysfunction. J Biol Chem. 292(27):11508-11530. PMID: 28522608.
  • Siddiqui S, Lustig A, Carter A, Sankar M, Daimon CM, Premont RT, Etienne H, van Gastel J, Azmi A, Janssens J, Becker KG, Zhang Y, Wood W, Lehrmann E, Martin JG, Martin B, Taub DD, Maudsley S. (2017) Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption. Aging (Albany NY). 9(3):706-740. PMID: 28260693.
  • Hardies K, de Kovel CG, Weckhuysen S, Asselbergh B, Geuens T, Deconinck T, Azmi A, May P, Brilstra E, Becker F, Barisic N, Craiu D, Braun KP, Lal D, Thiele H, Schubert J, Weber Y, van 't Slot R, Nürnberg P, Balling R, Timmerman V, Lerche H, Maudsley S, Helbig I, Suls A, Koeleman BP, De Jonghe P; autosomal recessive working group of the EuroEPINOMICS RES Consortium. (2015). Recessive mutations in SLC13A5 result in a loss of citrate transport and cause neonatal epilepsy, developmental delay and teeth hypoplasia. Brain. 138(Pt 11):3238-50. PMID: 26384929.
  • Janssens J, Etienne H, Idriss S, Azmi A, Martin B, Maudsley S. (2014). Systems-level G protein-coupled receptor therapy across a neurodegenerative continuum by the GLP-1 receptor system. Front Endocrinol. 5, 142. PMID: 25225492.
  • Almeida-Souza L, Asselbergh B, d'Ydewalle C, Moonens K, Goethals S, de Winter V, Azmi A, Irobi J, Timmermans JP, Gevaert K, Remaut H, Van Den Bosch L, Timmerman V, Janssens S. Small heat-shock protein HSPB1 mutants stabilize microtubules in Charcot-Marie-Tooth neuropathy. J Neurosci. 31(43):15320-8 (2011) PMID: 22031878.

All Publications Link http://www.ncbi.nlm.nih.gov/pubmed/?term=abdelkrim+azmi

Keywords


  • Chromatography

  • protein

  • metabolite

  • mass spectrometry

  • proteomics

  • metabolomics

  • protein chemistry

  • mass-tag labelling

  • biomarkers

  • plasma

  • iTRAQ

  • SILAC

  • GPCRs

  • phosphoproteomics

  • protein-protein interaction